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Oligonucleotide dendrimers: synthesis and use as polylabelled DNA probes.

Abstract:

Oligonucleotide dendrimers were synthesized using a novel phosphoramidite synthon, tris-2,2,2-[3-(4,4'-dimethoxytrityloxy) propyloxymethyl]ethyl- N , N -diisopropylaminocyanethoxy phosphoramidite. Label, incorporated using [gamma-32P]ATP and polynucleotide kinase, was increased in proportion to the number of 5'-ends. There was a similar increase in signal when these multiply labelled oligonucleotides were used as probes to oligonucleotide arrays. A dendrimeric oligonucleotide was used success...

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Publication status:
Published

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Publisher copy:
10.1093/nar/25.22.4447

Authors


Journal:
Nucleic acids research
Volume:
25
Issue:
22
Pages:
4447-4454
Publication date:
1997-11-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:9976b87e-51ab-435f-8a9a-10227b0f07e6
Source identifiers:
374939
Local pid:
pubs:374939

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