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The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.

Abstract:

It has recently been suggested that bisphosphonates may have direct antitumor effects in vivo, in addition to their therapeutic antiresorptive properties. Bisphosphonates can inhibit proliferation and cause apoptosis in human myeloma cells in vitro. In macrophages, bisphosphonate-induced apoptosis was recently found to be a result of inhibition of the mevalonate (MVA) pathway. The aim of this study was to determine whether bisphosphonates also affect human myeloma cells in vitro by inhibiting...

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Publication status:
Published

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Authors


Shipman, CM More by this author
Croucher, PI More by this author
Russell, RG More by this author
Helfrich, MH More by this author
Rogers, MJ More by this author
Journal:
Cancer research
Volume:
58
Issue:
23
Pages:
5294-5297
Publication date:
1998-12-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:996e382d-320b-45b3-805c-59ae6fb4584b
Source identifiers:
384074
Local pid:
pubs:384074

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