Journal article
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway.
- Abstract:
-
It has recently been suggested that bisphosphonates may have direct antitumor effects in vivo, in addition to their therapeutic antiresorptive properties. Bisphosphonates can inhibit proliferation and cause apoptosis in human myeloma cells in vitro. In macrophages, bisphosphonate-induced apoptosis was recently found to be a result of inhibition of the mevalonate (MVA) pathway. The aim of this study was to determine whether bisphosphonates also affect human myeloma cells in vitro by inhibiting...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Cancer research
- Volume:
- 58
- Issue:
- 23
- Pages:
- 5294-5297
- Publication date:
- 1998-12-01
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- Source identifiers:
-
384074
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:384074
- UUID:
-
uuid:996e382d-320b-45b3-805c-59ae6fb4584b
- Local pid:
- pubs:384074
- Deposit date:
- 2013-11-16
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- Copyright date:
- 1998
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