Journal article icon

Journal article

Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability.

Abstract:

Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through the assembly of multiple protein complexes involved in DNA repair, cell-cycle arrest, and transcriptional regulation. Here, we report the identification of a DNA damage-induced BRCA1 protein complex containing BCLAF1 and other key components of the mRNA-splicing machinery. In response to DNA damage, this complex regulates pre-mRNA splicing of a number ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Savage, KI More by this author
Gorski, JJ More by this author
Barros, EM More by this author
Expand authors...
Journal:
Molecular cell
Volume:
54
Issue:
3
Pages:
445-459
Publication date:
2014-05-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:99615cf1-dbc0-4bb6-baa8-2e7a6ebc32e2
Source identifiers:
463079
Local pid:
pubs:463079

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP