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Th1 cytokines are upregulated by adenoviral vectors in the brains of primed mice.

Abstract:

A major disadvantage of first generation adenoviral vectors for gene therapy in the brain is the immune response they elicit. Human adenovirus is a common respiratory virus and earlier exposure to it has important implications for gene therapy. We show that the immune response against E1-deleted adenoviral vectors in the brain is more deleterious in animals previously exposed to the virus. Analysis of cytokine mRNA revealed enhanced and prolonged upregulation of the Th1 proinflammatory cytoki...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Neuroreport
Volume:
19
Issue:
12
Pages:
1187-1192
Publication date:
2008-08-05
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
URN:
uuid:9959c08b-9ff4-424b-9e6c-f9b02f7155d8
Source identifiers:
113667
Local pid:
pubs:113667

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