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P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1.

Abstract:

The factors determining disease severity in malaria are complex and include host polymorphisms, acquired immunity and parasite virulence. Studies in Africa have shown that severe malaria is associated with the ability of erythrocytes infected with the parasite Plasmodium falciparum to bind uninfected erythrocytes and form rosettes. The molecular basis of resetting is not well understood, although a group of low-molecular-mass proteins called rosettins have been described as potential parasite...

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Publication status:
Published

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Publisher copy:
10.1038/40888

Authors


Moulds, JM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Miller, LH More by this author
Journal:
Nature
Volume:
388
Issue:
6639
Pages:
292-295
Publication date:
1997-07-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:9953cb98-a6bc-4ab6-bdc9-3d14d98a53d4
Source identifiers:
22248
Local pid:
pubs:22248

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