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Thesis

Translational control of autophagy rejuvenates immune responses

Abstract:

As our body's guardian, the immune system maintains systemic health through removal of pathogens, damage and cancer. Ageing of the immune system is associated with compromised immune responses as well as decreased tumour surveillance and is therefore a key risk factor for major diseases in the elderly. Adaptive immune responses are mediated by T and B lymphocytes, and failure in adaptive immunity is a particular hallmark of the ageing organism. Here we show that autophagy is impaired in aged ...

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Department:
The Kennedy Institute of Rheumatology

Contributors

Department:
The Kennedy Institute of Rheumatology
Role:
Supervisor
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Funding agency for:
Hanlin Zhang
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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