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Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues

Abstract:

Genome-wide-association-studies in the fields of reproductive medicine and endocrinology are yielding robust genetic variants associated with disease. Integrated genomic, transcriptomic and epigenomic molecular profiling studies are a common methodology to understand the biological pathways perturbed by these variants. However, molecular profiling resources do not include the tissue most relevant to many female reproductive traits, endometrium, whilst the parameters influencing variability o...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1080/15592294.2017.1367475

Authors


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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, Obstetrics & Gynaecology
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Department:
Oxford, MSD, Obstetrics & Gynaecology
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Funding agency for:
Rahmioglu, N
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Funding agency for:
Lindgren, CM
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Funding agency for:
Becker, CM
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Funding agency for:
Zondervan, KT
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Publisher:
Taylor & Francis Publisher's website
Journal:
Epigenetics Journal website
Volume:
12
Issue:
10
Pages:
897-908
Publication date:
2017-11-27
Acceptance date:
2017-08-09
DOI:
EISSN:
1559-2308
ISSN:
1559-2294
Pubs id:
pubs:728668
URN:
uri:99509fb1-667f-4f9a-8669-b5fb937d2fb9
UUID:
uuid:99509fb1-667f-4f9a-8669-b5fb937d2fb9
Local pid:
pubs:728668
Paper number:
10

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