Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial.

Journal article

BACKGROUND: Many infants admitted to hospital undergo repeated invasive procedures. Oral sucrose is frequently given to relieve procedural pain in neonates on the basis of its effect on behavioural and physiological pain scores. We assessed whether sucrose administration reduces pain-specific brain and spinal cord activity after an acute noxious procedure in newborn infants. METHODS: In this double-blind, randomised controlled trial, 59 newborn infants at University College Hospital (London, ...

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Authors: Slater, R; Cornelissen, L; Fabrizi, L; Patten, D; Yoxen, J

• Journal: Lancet
• Volume: 376
• Issue: 9748
• Pages: 1225-1232
• Publication date: 2010-10-01
• DOI: 10.1016/s0140-6736(10)61303-7
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Female; Double-Blind Method; Analgesia; Pain Measurement; Blood Specimen Collection; Electroencephalography; Heart Rate; Infant, Newborn; Electromyography; Brain; Water; Sucrose; Male; Oxygen; Infant Behavior; Facial Expression; Humans; Spine; Evoked Potentials; Administration, Oral