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Journal article

Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions.

Abstract:

Ly108, a glycoprotein of the signaling lymphocytic activation molecule family of cell surface receptors expressed by T, B, NK, and APCs has been shown to have a role in NK cell cytotoxicity and T cell cytokine responses. In this study, we describe that CD4(+) T cells from mice with a targeted disruption of exons 2 and 3 of Ly108 (Ly108(DeltaE2+3)) produce significantly less IL-4 than wild-type CD4(+) cells, as judged by in vitro assays and by in vivo responses to cutaneous infection with Leis...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
174
Issue:
10
Pages:
5931-5935
Publication date:
2005-05-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:99489ac4-0617-463a-94a3-5d84a25dcb36
Source identifiers:
55457
Local pid:
pubs:55457

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