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Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release

Abstract:

Somatostatin secretion from pancreatic islet δ-cells is stimulated by elevated glucose levels, but the underlying mechanisms have only partially been elucidated. Here we show that glucose-induced somatostatin secretion (GISS) involves both membrane potential-dependent and -independent pathways. Although glucose-induced electrical activity triggers somatostatin release, the sugar also stimulates GISS via a cAMP-dependent stimulation of CICR and exocytosis of somatostatin. The latter effect is ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1085/jgp.201912351

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Role:
Author
ORCID:
0000-0002-8883-176X
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Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of General Physiology Journal website
Volume:
151
Issue:
9
Pages:
1094-1115
Publication date:
2019-07-29
Acceptance date:
2019-07-09
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
Pmid:
31358556
Pubs id:
pubs:1038662
UUID:
uuid:994835b8-0b86-4e41-b6f0-e4a677e0cfde
Source identifiers:
1038662
Local pid:
pubs:1038662
Language:
English
Keywords:

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