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Journal article

Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome.

Abstract:

Rett syndrome (RTT) is a severe form of mental retardation, which is caused by spontaneous mutations in the X-linked gene MECP2. How the loss of MeCP2 function leads to RTT is currently unknown. Mice lacking the Mecp2 gene initially show normal postnatal development but later acquire neurological phenotypes, including heightened anxiety, that resemble RTT. The MECP2 gene encodes a methyl-CpG-binding protein that can act as a transcriptional repressor. Using cDNA microarrays, we found that Mec...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddi229

Authors


Kriaucionis, S More by this author
Roloff, TC More by this author
Selfridge, J More by this author
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Journal:
Human molecular genetics
Volume:
14
Issue:
15
Pages:
2247-2256
Publication date:
2005-08-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:9946a756-8893-4099-9320-e9cf8f9135a9
Source identifiers:
90264
Local pid:
pubs:90264

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