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The impact project: Improving the impact of existing malaria products – Acts

Abstract:

The antimalarial dihydroartemisinin-piperaquine (DHA-PPQ) is one of the recommended drugs to treat uncomplicated Plasmodium falciparum malaria. However, DHA-PPQ has a relatively narrow, poorly defined therapeutic dose range and it is unclear whether PPQ concentration-dependent cardiotoxicity (QTc prolongation) poses a clinical risk for specific subgroups. Uncertainty about the exact safe upper PPQ concentration threshold and recognition of the vulnerability of children has led WHO to consider...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1136/bmjgh-2016-000260.66

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Institution:
University of Oxford
Division:
Medical Sciences Division
Role:
Author
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ Global Health Journal website
Volume:
2
Issue:
Suppl 2
Pages:
A26.1-A26
Publication date:
2017-02-05
DOI:
ISSN:
2059-7908
Pubs id:
pubs:745818
URN:
uri:99370a1b-da52-4151-98b2-d8557720fd8b
UUID:
uuid:99370a1b-da52-4151-98b2-d8557720fd8b
Local pid:
pubs:745818

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