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Absence of cyclin-D2 and Bcl-2 expression within the germinal centre type of diffuse large B-cell lymphoma identifies a very good prognostic subgroup of patients.

Abstract:

AIMS: To validate and improve the existing algorithm (proposed by Hans et al.) to classify diffuse large B-cell lymphoma (DLBCL). METHODS AND RESULTS: Tissue microarrays constructed from 81 patients with DLBCL were studied by immunohistochemistry for expression of CD10, Bcl-6, MUM1, Bcl-2, cyclin-D2, FOXP1 and PKC-gamma proteins. Cases were classified as either germinal centre B-like (GCB) or non-GC according to Hans et al. An alternative classification was also employed, in which cases posi...

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Publication status:
Published

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Authors


Horncastle, D More by this author
Elderfield, K More by this author
Banham, AH More by this author
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Journal:
Histopathology
Volume:
51
Issue:
1
Pages:
70-79
Publication date:
2007-07-05
DOI:
EISSN:
1365-2559
ISSN:
0309-0167
URN:
uuid:99304164-8a5d-4922-8474-811095beb669
Source identifiers:
210328
Local pid:
pubs:210328

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