COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.

Journal article

BACKGROUND: While multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are primarily inflammatory and degenerative disorders respectively, there is increasing evidence for shared cellular mechanisms that may affect disease progression, particularly glial responses. Cyclooxygenase 2 (COX-2) inhibition prolongs survival and cannabinoids ameliorate progression of clinical disease in animal models of ALS and MS respectively, but the mechanism is uncertain. Therefore, three key molecul...

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Authors: Yiangou, Y; Facer, P; Durrenberger, P; Chessell, I; Naylor, A

• Publication status: Published
• Journal: BMC neurology
• Volume: 6
• Pages: 12
• Publication date: 2006-01-01
• DOI: 10.1186/1471-2377-6-12
• EISSN: 1471-2377
• ISSN: 1471-2377
• Language: English
• Keywords: Protein Binding; Blotting, Western; Spinal Cord; Cyclooxygenase 2; Immunohistochemistry; Macrophages; Postmortem Changes; Microglia; Amyotrophic Lateral Sclerosis; Humans; Aged; Antigens, Differentiation, Myelomonocytic; Middle Aged; Multiple Sclerosis; Receptor, Cannabinoid, CB2; Antigens, CD; Isoquinolines; Male; Receptors, Purinergic P2X7; Receptors, Purinergic P2; Female; Radioligand Assay; Membrane Proteins