Genetics of sporadic amyotrophic lateral sclerosis.

Journal article

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized clinically by rapidly progressive paralysis leading ultimately to death from respiratory failure. There is substantial evidence suggesting that ALS is a heritable disease, and a number of genes have been identified as being causative in familial ALS. In contrast, the genetics of the much commoner sporadic form of the disease is poorly understood and no single gene has been definitively shown to increase the...

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Authors: Schymick, J; Talbot, K; Traynor, B

• Journal: Human molecular genetics
• Volume: 16 Spec No. 2
• Issue: R2
• Pages: R233-R242
• Publication date: 2007-10-01
• DOI: 10.1093/hmg/ddm215
• EISSN: 1460-2083
• ISSN: 0964-6906
• Language: English
• Keywords: Vascular Endothelial Growth Factor A; RNA-Binding Proteins; Neurofilament Proteins; Membrane Proteins; SMN Complex Proteins; Membrane Glycoproteins; Aryldialkylphosphatase; Ribonuclease, Pancreatic; Humans; Histocompatibility Antigens Class I; Microtubule-Associated Proteins; Superoxide Dismutase; Intermediate Filament Proteins; Nerve Degeneration; Nerve Tissue Proteins; Endosomal Sorting Complexes Required for Transport; Cyclic AMP Response Element-Binding Protein; Amyotrophic Lateral Sclerosis; DNA-(Apurinic or Apyrimidinic Site) Lyase; Intercellular Signaling Peptides and Proteins