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New synthetic seven-membered 1-azasugars displaying potent inhibition towards glycosidases and glucosylceramide transferase.

Abstract:

Several members of a new family of seven-membered azasugars, which can be seen as 1-azasugar ring homologues, have been obtained by simple chemical transformations starting from a sugar-derived azidolactol. Unlike their piperidine counterparts, these molecules are chemically stable when they possess a hydroxy group at the pseudo-C-2 position. Biological assays with a range of carbohydrate-processing enzymes have revealed interesting potential for these compounds. A trihydroxymethyl-substitute...

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Publication status:
Published

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Publisher copy:
10.1002/cbic.200700496

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Journal:
Chembiochem : a European journal of chemical biology
Volume:
9
Issue:
2
Pages:
253-260
Publication date:
2008-01-05
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
URN:
uuid:990d54c7-5a13-4c99-ba5c-c5bcd9a73710
Source identifiers:
101076
Local pid:
pubs:101076

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