Primary sclerosing cholangitis associated with rheumatoid arthritis and HLA DR4: is the association a marker of patients with progressive liver disease?

Journal article

In four cases we describe the unique association of primary sclerosing cholangitis (PSC) and rheumatoid arthritis (RA). In three of the cases the liver disease was unusually progressive, proceeding to cirrhosis in 14, 18 and 48 months from diagnosis. The three cases with progressive liver disease and ulcerative colitis were all HLA type DR4. The fourth patient also suffered from coeliac disease in addition to PSC and RA and has remained asymptomatic over 7 years of follow-up. RA in associatio...

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Authors: Gow, P; Fleming, K; Chapman, R

• Publication status: Published
• Journal: Journal of hepatology
• Volume: 34
• Issue: 4
• Pages: 631-635
• Publication date: 2001-04-01
• DOI: 10.1016/s0168-8278(00)00060-x
• EISSN: 1600-0641
• ISSN: 0168-8278
• Language: English
• Keywords: Female; Humans; Vasculitis; Disease Progression; Sclerosis; Middle Aged; Adult; Male; HLA-DR4 Antigen; Aged; Arthritis, Rheumatoid; Biological Markers