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Journal article

Crystal structure of a heparin- and integrin-binding segment of human fibronectin.

Abstract:

The crystal structure of human fibronectin (FN) type III repeats 12-14 reveals the primary heparin-binding site, a clump of positively charged residues in FN13, and a putative minor site approximately 60 A away in FN14. The IDAPS motif implicated in integrin alpha4beta1 binding is at the FN13-14 junction, rendering the critical Asp184 inaccessible to integrin. Asp184 clamps the BC loop of FN14, whose sequence (PRARI) is reminiscent of the synergy sequence (PHSRN) of FN9. Mutagenesis studies p...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/18.6.1468

Authors


Askari, JA More by this author
Humphries, MJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Journal:
The EMBO journal
Volume:
18
Issue:
6
Pages:
1468-1479
Publication date:
1999-03-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:98fb4313-af7d-4145-849c-8e521b331734
Source identifiers:
28571
Local pid:
pubs:28571

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