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Studies on the mechanisms by which clenbuterol, a beta-adrenoceptor agonist, enhances 5-HT-mediated behaviour and increases metabolism of 5-HT in the brain of the rat.

Abstract:

The head twitch response in mice produced by injection of 5-hydroxytryptophan (100 mg/kg i.p.) and carbidopa (25 mg/kg i.p.) was enhanced by administration of clenbuterol (0.5 mg/kg i.p.), a beta-adrenoceptor agonist. Clenbuterol also enhanced the hyperactivity syndrome in rats produced by quipazine (25 mg/kg i.p.), a 5-hydroxytryptamine (5-HT) agonist. This enhancement was not prevented by depletion of 5-HT in brain with p-chlorophenylalanine or after pretreatment with prazosin. The behaviou...

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Publication status:
Published

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Journal:
Neuropharmacology
Volume:
22
Issue:
6
Pages:
739-749
Publication date:
1983-06-05
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:98faf93b-aee9-4567-9889-45a83c79b0b2
Source identifiers:
185954
Local pid:
pubs:185954

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