Journal article
Studies on the mechanisms by which clenbuterol, a beta-adrenoceptor agonist, enhances 5-HT-mediated behaviour and increases metabolism of 5-HT in the brain of the rat.
- Abstract:
-
The head twitch response in mice produced by injection of 5-hydroxytryptophan (100 mg/kg i.p.) and carbidopa (25 mg/kg i.p.) was enhanced by administration of clenbuterol (0.5 mg/kg i.p.), a beta-adrenoceptor agonist. Clenbuterol also enhanced the hyperactivity syndrome in rats produced by quipazine (25 mg/kg i.p.), a 5-hydroxytryptamine (5-HT) agonist. This enhancement was not prevented by depletion of 5-HT in brain with p-chlorophenylalanine or after pretreatment with prazosin. The behaviou...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/0028-3908(83)90098-9
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Bibliographic Details
- Journal:
- Neuropharmacology
- Volume:
- 22
- Issue:
- 6
- Pages:
- 739-749
- Publication date:
- 1983-06-01
- DOI:
- EISSN:
-
1873-7064
- ISSN:
-
0028-3908
- Source identifiers:
-
185954
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:185954
- UUID:
-
uuid:98faf93b-aee9-4567-9889-45a83c79b0b2
- Local pid:
- pubs:185954
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1983
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