Studies on the mechanisms by which clenbuterol, a beta-adrenoceptor agonist, enhances 5-HT-mediated behaviour and increases metabolism of 5-HT in the brain of the rat.

Nimgaonkar, VL; Green, AR; Cowen, PJ; Heal, DJ; Grahame-Smith, DG; Deakin, JF

Abstract:

The head twitch response in mice produced by injection of 5-hydroxytryptophan (100 mg/kg i.p.) and carbidopa (25 mg/kg i.p.) was enhanced by administration of clenbuterol (0.5 mg/kg i.p.), a beta-adrenoceptor agonist. Clenbuterol also enhanced the hyperactivity syndrome in rats produced by quipazine (25 mg/kg i.p.), a 5-hydroxytryptamine (5-HT) agonist. This enhancement was not prevented by depletion of 5-HT in brain with p-chlorophenylalanine or after pretreatment with prazosin. The behaviou...

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APA Style

Nimgaonkar, V. L., Green, A. R., Cowen, P. J., Heal, D. J., Grahame-Smith, D. G., & Deakin, J. F. (1983). Studies on the mechanisms by which clenbuterol, a beta-adrenoceptor agonist, enhances 5-HT-mediated behaviour and increases metabolism of 5-HT in the brain of the rat. Neuropharmacology, 22(6), 739–749.

MLA Style

Nimgaonkar, V. L., et al. “Studies on the Mechanisms by Which Clenbuterol, a Beta-Adrenoceptor Agonist, Enhances 5-HT-Mediated Behaviour and Increases Metabolism of 5-HT in the Brain of the Rat.” Neuropharmacology, vol. 22, no. 6, Neuropharmacology, 1983, pp. 739–49.

Chicago Style

Nimgaonkar, VL, AR Green, PJ Cowen, DJ Heal, DG Grahame-Smith, and JF Deakin. 1983. “Studies on the Mechanisms by Which Clenbuterol, a Beta-Adrenoceptor Agonist, Enhances 5-HT-Mediated Behaviour and Increases Metabolism of 5-HT in the Brain of the Rat.” Neuropharmacology 22 (6): 739–49.
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