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Ex vivo adenovirus-mediated gene transfer and immunomodulatory protein production in human cornea.

Abstract:

One attractive strategy to prevent or control allograft rejection is to genetically modify the donor tissue before transplantation. In this study, we have examined the feasibility of gene transfer to human corneal endothelium, using a number of recombinant adenovirus constructs. Ex vivo infection of human corneas with adenoviral vectors containing lacZ, under transcriptional control of either cytomegalovirus (CMV) or Rous sarcoma virus (RSV) promoters, provided high-level gene expression, whi...

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Publisher copy:
10.1038/sj.gt.3300443

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Journal:
Gene therapy
Volume:
4
Issue:
7
Pages:
639-647
Publication date:
1997-07-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:98f49d43-12b7-46d6-9327-293e2061c4fb
Source identifiers:
115395
Local pid:
pubs:115395

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