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Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding.

Abstract:

Using a cytological assay to monitor the successive chromatin association of replication proteins leading to replication initiation, we have investigated the function of fission yeast Cdc23/Mcm10 in DNA replication. Inactivation of Cdc23 before replication initiation using tight degron mutations has no effect on Mcm2 chromatin association, and thus pre-replicative complex (pre-RC) formation, although Cdc45 chromatin binding is blocked. Inactivating Cdc23 during an S phase block after Cdc45 ha...

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Publication status:
Published

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Publisher copy:
10.1091/mbc.e03-02-0090

Authors


Lindner, K More by this author
Brimage, L More by this author
Franklin, R More by this author
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Journal:
Molecular biology of the cell
Volume:
14
Issue:
9
Pages:
3876-3887
Publication date:
2003-09-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:98ee7e1c-0313-482c-a97f-924de3aebbed
Source identifiers:
209324
Local pid:
pubs:209324

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