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Structural insight into BLM recognition by TopBP1

Abstract:

Topoisomerase IIβ binding protein 1 (TopBP1) is a critical protein-protein interaction hub in DNA replication checkpoint control. It was proposed that TopBP1 BRCT5 interacts with Bloom syndrome helicase (BLM) to regulate genome stability through either phospho-Ser304 or phospho-Ser338 of BLM. Here we show that TopBP1 BRCT5 specifically interacts with the BLM region surrounding pSer304, not pSer338. Our crystal structure of TopBP1 BRCT4/5 bound to BLM reveals recognition of pSer304 by a conser...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.str.2017.08.005

Authors


Edwards, RA More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
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National Cancer Institute More from this funder
Canadian Institutes of Health Research More from this funder
Natural Sciences and Engineering Research Council of Canada More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Structure Journal website
Volume:
25
Issue:
10
Pages:
1582–1588.e3
Publication date:
2017-09-14
Acceptance date:
2017-08-15
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Pubs id:
pubs:729900
URN:
uri:98eb4374-f2f0-4dbf-a9fc-c5404d690c46
UUID:
uuid:98eb4374-f2f0-4dbf-a9fc-c5404d690c46
Local pid:
pubs:729900

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