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"Polar patch" proteases as glycopeptiligases.

Abstract:
The strategy of combined site directed mutagenesis and chemical modification with polar prosthetic groups was used to broaden substrate specificity of proteases resulting in the first successful formation of glycopeptides through the use of glucoamino acid acyl donors in yields of up to 90%.
Publication status:
Published

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Publisher copy:
10.1039/b412030b

Authors


Doores, KJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Chemical communications (Cambridge, England)
Issue:
2
Pages:
168-170
Publication date:
2005-01-05
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
URN:
uuid:98b6bbd9-ac22-4b41-ae5f-dc27d3b4335e
Source identifiers:
33006
Local pid:
pubs:33006

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