Genetic variants associated with Lp(a) lipoprotein level and coronary disease.

Journal article

BACKGROUND: An increased level of Lp(a) lipoprotein has been identified as a risk factor for coronary artery disease that is highly heritable. The genetic determinants of the Lp(a) lipoprotein level and their relevance for the risk of coronary disease are incompletely understood. METHODS: We used a novel gene chip containing 48,742 single-nucleotide polymorphisms (SNPs) in 2100 candidate genes to test for associations in 3145 case subjects with coronary disease and 3352 control subjects. Repl...

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Authors: Clarke, R; Peden, J; Hopewell, J; Kyriakou, T; Goel, A

• Publication status: Published
• Journal: New England journal of medicine
• Volume: 361
• Issue: 26
• Pages: 2518-2528
• Publication date: 2009-12-01
• DOI: 10.1056/nejmoa0902604
• EISSN: 1533-4406
• ISSN: 0028-4793
• Language: English
• Keywords: Coronary Disease; PROCARDIS Consortium; Genetic Predisposition to Disease; Likelihood Functions; Case-Control Studies; Polymorphism, Single Nucleotide; Myocardial Infarction; Kringles; Genetic Markers; Lipoprotein(a); Oligonucleotide Array Sequence Analysis; Risk Factors; Regression Analysis; Humans; Genotype; Genome-Wide Association Study