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Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells.

Abstract:

BACKGROUND: In a specialized epithelial cell such as the Drosophila photoreceptor, a conserved set of proteins is essential for the establishment of polarity, its maintenance, or both--in Drosophila, these proteins include the apical factors Bazooka, D-atypical protein kinase C, and D-Par6 together with D-Ecadherin. However, little is known about the mechanisms by which such apical factors might regulate the differentiation of the apical membrane into functional domains such as an apical-most...

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Publisher copy:
10.1016/j.cub.2005.11.068

Authors


Goberdhan, DC More by this author
Collinson, L More by this author
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Journal:
Current biology : CB
Volume:
16
Issue:
2
Pages:
140-149
Publication date:
2006-01-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:98aa274f-46d6-4899-ab98-ac76e1764ff4
Source identifiers:
114164
Local pid:
pubs:114164

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