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Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells.

Abstract:

Suppression by natural CD4(+)CD25(+) regulatory T cells (Tregs) is one mechanism by which tolerance is maintained. However, the way in which Tregs mediate suppression is not well understood. Here, we show that secreted phospholipase A2 (sPLA2)-IID is selectively produced by Tregs. sPLA2-IID is a potent mediator of Treg function, because it strongly suppressed proliferation of CD4(+) and CD8(+) T cells in vitro and in vivo in a manner independent of its catalytic activity. Furthermore, sPLA2-I...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0812569106

Authors


von Allmen, CE More by this author
Schmitz, N More by this author
Hinton, HJ More by this author
Kurrer, MO More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
28
Pages:
11673-11678
Publication date:
2009-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:98a3aacb-9e5d-4854-a91b-1fdcc1cba536
Source identifiers:
422379
Local pid:
pubs:422379

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