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Review: Improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations.

Abstract:

Because 8-aminoquinolines affect critical survival stages of Plasmodium parasites, treatment and control of malaria could be markedly improved by more widespread use of these drugs; however, hemolytic toxicity, which is widely prevalent in G6PD-deficient patients, severely constrains this use. Primaquine was approved more than 50 years ago after extensive clinical testing. Review of the mid-20th century literature in the light of present understanding of pharmacokinetics and metabolism sugges...

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Publication status:
Published

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Publisher copy:
10.4269/ajtmh.2011.11-0498

Authors


Melendez, V More by this author
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Journal:
The American journal of tropical medicine and hygiene
Volume:
85
Issue:
6
Pages:
1010-1014
Publication date:
2011-12-05
DOI:
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:98976f87-607b-4ed4-8813-99767561b2f5
Source identifiers:
216145
Local pid:
pubs:216145

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