Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals.

Journal article

BACKGROUND: People at ultra high risk (UHR) of psychosis have an elevated risk of developing a psychotic disorder, but it is difficult to predict which individuals will make a transition to frank illness. We investigated whether functional magnetic resonance imaging (fMRI) in conjunction with a phonological fluency task at presentation could distinguish subjects who subsequently developed psychosis from those who did not. METHODS: Sixty-five subjects (41 with an UHR and 24 healthy controls) w...

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Authors: Allen, P; Luigjes, J; Howes, O; Egerton, A; Hirao, K

• Journal: Schizophrenia bulletin
• Volume: 38
• Issue: 6
• Pages: 1268-1276
• Publication date: 2012-11-01
• DOI: 10.1093/schbul/sbr194
• EISSN: 1745-1701
• ISSN: 0586-7614
• Language: English
• Keywords: Brain; Hippocampus; Prodromal Symptoms; Radiopharmaceuticals; Pons; Magnetic Resonance Imaging; Prefrontal Cortex; Female; Adult; Risk; Male; Brain Mapping; Longitudinal Studies; Mesencephalon; Psychotic Disorders; Speech Production Measurement; Positron-Emission Tomography; Humans; Case-Control Studies; Functional Neuroimaging; Dihydroxyphenylalanine; Fluorine Radioisotopes; Disease Progression