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Clearance of genotype 1b hepatitis C virus in chimpanzees in the presence of vaccine-induced E1-neutralizing antibodies.

Abstract:

Accumulating evidence indicates that neutralizing antibodies play an important role in protection from chronic hepatitis C virus (HCV) infection. Efforts to elicit such responses by immunization with intact heterodimeric E1E2 envelope proteins have met with limited success. To determine whether antigenic sites, which are not exposed by the combined E1E2 heterodimer structure, are capable of eliciting neutralizing antibody responses, we expressed and purified each as separate recombinant prote...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jir423

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Journal:
The Journal of infectious diseases
Volume:
204
Issue:
6
Pages:
837-844
Publication date:
2011-09-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:9895a993-d86f-4403-ba47-b42b2b6e4528
Source identifiers:
179586
Local pid:
pubs:179586

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