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Identification of vaccine antigens using integrated proteomic analyses of surface immunogens from serogroup B Neisseria meningitidis

Abstract:

Meningococcal surface proteins capable of evoking a protective immune response are candidates for inclusion in protein-based vaccines against serogroup B Neisseria meningitidis (NmB). In this study, a 2-dimensional (2-D) gel-based platform integrating surface and immune-proteomics was developed to characterize NmB surface protein antigens. The surface proteome was analyzed by differential 2-D gel electrophoresis following treatment of live bacteria with proteinase K. Alongside, proteins recog...

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Publisher copy:
10.1016/j.jprot.2014.02.013

Authors


Tsolakos, N More by this author
Feavers, IM More by this author
Wheeler, JX More by this author
Brookes, C More by this author
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Journal:
Journal of Proteomics
Volume:
101
Pages:
63-76
Publication date:
2014-04-14
DOI:
EISSN:
1876-7737
ISSN:
1874-3919
URN:
uuid:9893ad11-5a35-4e4a-a032-598d2b9d9def
Source identifiers:
452159
Local pid:
pubs:452159

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