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Journal article

MR1-dependent immune surveillance of the skin contributes to pathogenesis and is a photobiological target of UV light therapy in a mouse model of atopic dermatitis

Abstract:

Background: Mucosal-associated invariant T (MAIT) cells are unconventional T cells which recognize microbial metabolites presented by the major histocompatibility complex class I-related molecule MR1. Although MAIT cells have been shown to reside in human and murine skin, their contribution to atopic dermatitis (AD), an inflammatory skin disease associated with barrier dysfunction and microbial translocation, has not yet been determined.

Methods: G...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/all.14994

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
ORCID:
0000-0002-2505-5222
Publisher:
Wiley
Journal:
Allergy More from this journal
Volume:
76
Issue:
10
Pages:
3155-3170
Publication date:
2021-07-07
Acceptance date:
2021-05-24
DOI:
EISSN:
1398-9995
ISSN:
0105-4538
Pmid:
34185885
Language:
English
Keywords:
Pubs id:
1327742
Local pid:
pubs:1327742
Deposit date:
2023-02-07

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