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Molecular diagnosis of the myeloproliferative neoplasms: UK guidelines for the detection of JAK2 V617F and other relevant mutations

Abstract:

Molecular genetic assays for the detection of the JAK2 V617F (c.1849G>T) and other pathogenetic mutations within JAK2 exon 12 and MPL exon 10 are part of the routine diagnostic workup for patients presenting with erythrocytosis, thrombocytosis or otherwise suspected to have a myeloproliferative neoplasm. A wide choice of techniques are available for the detection of these mutations, leading to potential difficulties for clinical laboratories in deciding upon the most appropriate assay, whi...

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Publisher copy:
10.1111/bjh.12075

Authors


Godfrey, AL More by this author
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Journal:
British Journal of Haematology
Volume:
160
Issue:
1
Pages:
25-34
Publication date:
2013
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:9874acf3-0f31-4412-a9cf-d40fe1e28a7b
Source identifiers:
368686
Local pid:
pubs:368686

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