Short-term antidepressant administration reduces negative self-referential processing in the medial prefrontal cortex in subjects at risk for depression.

Journal article

Depression has been associated with changes in responses within the medial prefrontal cortex (mPFC) during emotional information processing. Antidepressant drug treatment has been shown to modify neural responses in healthy volunteers early in treatment within similar circuitry. It is unclear, however, whether the same early effect occurs in depressed patients, before changes in mood. The current study therefore investigated the effects of 7-days administration of the selective serotonin-upta...

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Authors: Di Simplicio, M; Norbury, R; Harmer, C

• Publication status: Published
• Journal: Molecular psychiatry
• Volume: 17
• Issue: 5
• Pages: 503-510
• Publication date: 2012-05-01
• DOI: 10.1038/mp.2011.16
• EISSN: 1476-5578
• ISSN: 1359-4184
• Language: English
• Keywords: Prefrontal Cortex; Adult; Functional Neuroimaging; Magnetic Resonance Imaging; Citalopram; Emotions; Psychiatric Status Rating Scales; Female; Male; Cerebrovascular Circulation; Personality; Humans; Depression; Psychomotor Performance