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Twenty-four-hour normothermic perfusion of discarded human kidneys with urine recirculation

Abstract:

Transportable normothermic kidney perfusion for 24 hours or longer could enable viability assessment of marginal grafts, increased organ use, and improved transplant logistics. Eleven clinically declined kidneys were perfused normothermically, with 6 being from donors after brain death (median cold ischemia time 33 ± 36.9 hours) and 5 being from donors after circulatory death (36.2 ± 38.3 hours). Three kidneys were perfused using Ringer’s lactate to replace excreted urine volume, and 8 kidney...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1111/ajt.14932

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Soares, MF More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
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Engineering and Physical Sciences Research Council More from this funder
Publisher:
John Wiley and Sons, Inc. Publisher's website
Journal:
American Journal of Transplantation Journal website
Volume:
19
Issue:
1
Pages:
178-192
Publication date:
2018-05-14
Acceptance date:
2018-05-06
DOI:
EISSN:
1600-6143
ISSN:
1600-6135
Pubs id:
pubs:847904
URN:
uri:985a16a6-a36b-46e6-b085-ace8631695c9
UUID:
uuid:985a16a6-a36b-46e6-b085-ace8631695c9
Local pid:
pubs:847904

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