Proteomic analysis of colony morphology variants of Burkholderia pseudomallei defines a role for the arginine deiminase system in bacterial survival.

Journal article

Colony morphology variation of Burkholderia pseudomallei is a notable feature of a proportion of primary clinical cultures from patients with melioidosis. Here, we examined the hypothesis that colony morphology switching results in phenotypic changes associated with enhanced survival under adverse conditions. We generated isogenic colony morphology types II and III from B. pseudomallei strain 153 type I, and compared their protein expression profiles using 2D gel electrophoresis. Numerous pro...

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Authors: Chantratita, N; Tandhavanant, S; Wikraiphat, C; Trunck, L; Rholl, D

• Publication status: Published
• Journal: Journal of proteomics
• Volume: 75
• Issue: 3
• Pages: 1031-1042
• Publication date: 2012-01-01
• DOI: 10.1016/j.jprot.2011.10.015
• EISSN: 1876-7737
• ISSN: 1874-3919
• Language: English
• Keywords: Species Specificity; Bacterial Proteins; RNA, Bacterial; Mutation; Burkholderia pseudomallei; Humans; Gene Expression Regulation, Bacterial; Proteomics; Melioidosis; Animals