Antigenic diversity and size diversity of Plasmodium falciparum antigens in isolates from Gambian patients. I. S-antigens.

Journal article

Ring-stage asexual parasites of P. falciparum were collected from six Gambian children and the S-antigens radiolabelled by 3H-glycine uptake during in vitro culture up to rupture of infected cells and merozoite release. Ouchterlony double diffusion of boiled culture supernatants against a panel of adult Gambian sera identified one S-antigen precipitin arc for five isolates and two precipitin arcs for one isolate. Five of the six isolates were serologically distinct. Analysis of S-antigens by ...

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Authors: Howard, R; Panton, L; Marsh, K; Ling, I; Winchell, E

• Publication status: Published
• Journal: Parasite immunology
• Volume: 8
• Issue: 1
• Pages: 39-55
• Publication date: 1986-01-01
• DOI: 10.1111/j.1365-3024.1986.tb00832.x
• EISSN: 1365-3024
• ISSN: 0141-9838
• Language: English
• Keywords: Antibody Specificity; Gambia; Child; Electrophoresis, Polyacrylamide Gel; Humans; Immunosorbent Techniques; Plasmodium falciparum; Molecular Weight; Glycine; Epitopes; Antibodies; Antigens, Protozoan; Adult; Malaria