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Inhibition of signal transducer and activator transcription factor 3 in rats with acute hepatic failure.

Abstract:

In fulminant hepatic failure, survival is not possible without recovery of sufficient hepatocyte mass. Remarkably, only a few studies exist that provide insight into the mechanisms that control proliferation of residual hepatocytes after extensive hepatocyte loss. In this regard, the role of growth-regulatory factors, including pro-inflammatory cytokines such as interleukin-6 (IL-6), is not well understood. In the present study we show that in rats with critically low (10%) hepatocyte mass, w...

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Publisher copy:
10.1006/bbrc.2000.2881

Authors


Kamohara, Y More by this author
Sugiyama, N More by this author
Mizuguchi, T More by this author
Inderbitzin, D More by this author
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Journal:
Biochemical and biophysical research communications
Volume:
273
Issue:
1
Pages:
129-135
Publication date:
2000-06-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:9840bc0b-8a42-47bb-9711-baec5f88c48e
Source identifiers:
366050
Local pid:
pubs:366050

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