Inhibition of signal transducer and activator transcription factor 3 in rats with acute hepatic failure.
In fulminant hepatic failure, survival is not possible without recovery of sufficient hepatocyte mass. Remarkably, only a few studies exist that provide insight into the mechanisms that control proliferation of residual hepatocytes after extensive hepatocyte loss. In this regard, the role of growth-regulatory factors, including pro-inflammatory cytokines such as interleukin-6 (IL-6), is not well understood. In the present study we show that in rats with critically low (10%) hepatocyte mass, w...Expand abstract
- Publisher copy:
- Biochemical and biophysical research communications
- Publication date:
- Source identifiers:
- Local pid:
- Copyright date: