Journal article
Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression.
- Abstract:
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To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto-Kakizaki (GK) rats and Brown-Norway (BN) controls, which contain well-defined blocks (1Mb-183Mb) of genetic polymorphisms, and in 123 genetically heterogeneous rats of an (GKxBN)F2 offspring. Within each congenic we identified 73 to 1,351 differentially expressed genes (DEG), on...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.3MB, Terms of use)
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- Publisher copy:
- 10.1534/g3.116.033274
Authors
Funding
+ Wellcome Trust
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Grant:
Senior Fellowship in Basic Biomedical Science (057733)
Core Award grant (075491/Z/04
090532/Z/09/Z
083573/Z/07/Z
Bibliographic Details
- Publisher:
- Genetics Society of America
- Journal:
- G3 More from this journal
- Volume:
- 6
- Issue:
- 11
- Pages:
- 3671-3683
- Publication date:
- 2016-09-19
- Acceptance date:
- 2016-09-14
- DOI:
- EISSN:
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2160-1836
- ISSN:
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2160-1836
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:645840
- UUID:
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uuid:983586df-4949-454b-99fa-8b98ba658b7d
- Local pid:
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pubs:645840
- Source identifiers:
-
645840
- Deposit date:
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2016-11-09
Terms of use
- Copyright holder:
- Kaisaki et al
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Kaisaki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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