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Thesis

Mathematical modelling of mitotic exit control in budding yeast cell cycle

Abstract:

The operating principles of complex regulatory networks are more easily understood with mathematical modelling than by intuitive reasoning. In this thesis, I study the dynamics of the mitotic exit control system in budding yeast. I present a comprehensive mathematical model, which provides a system’s-level understanding of the mitotic exit process. This model captures the dynamics of classic experimental situations reported in the literature, and overcomes a number of limitations present i...

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Institution:
University of Oxford
Research group:
Professor Bela Novak
Oxford college:
Merton College
Department:
Medical Sciences Division - Biochemistry

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:982b3244-328d-4b76-b333-50287a753bc0
Local pid:
ora:6459
Language:
English
Keywords:
Subjects:

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