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Structure of the C-terminal domain of the clock protein KaiA in complex with a KaiC-derived peptide: implications for KaiC regulation.

Abstract:

Circadian clocks are widespread endogenous mechanisms that control the temporal pattern of diverse biological processes, including gene transcription. KaiA is the positive element of the cyanobacterial clock because KaiA overexpression elevates transcription levels of clock components. Recently, we showed that the structure of KaiA is that of a domain-swapped homodimer. The N-terminal domain is a pseudo-receiver; thus, it is likely to be involved in signal transduction in the clock-resetting ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0403037101

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
LiWang, AC More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
30
Pages:
10925-10930
Publication date:
2004-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:9820c996-a142-49e9-883d-690d26605f69
Source identifiers:
196796
Local pid:
pubs:196796

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