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Journal article

Engaging neuroscience to advance translational research in brain barrier biology.

Abstract:
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.
Publication status:
Published

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Publisher copy:
10.1038/nrn2995

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Journal:
Nature reviews. Neuroscience
Volume:
12
Issue:
3
Pages:
169-182
Publication date:
2011-03-05
DOI:
EISSN:
1471-0048
ISSN:
1471-003X
URN:
uuid:981e0fb3-04d4-4c5f-9c33-9f9b88fed2eb
Source identifiers:
124494
Local pid:
pubs:124494

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