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Journal article

TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype.

Abstract:

TDP-43 immunoreactive (TDP-43-ir) pathological changes were investigated in the temporal cortex and hippocampus of 11 patients with autosomal dominant familial forms of Alzheimer's disease (FAD), 169 patients with sporadic AD [85 with early onset disease (EOAD) (i.e before 65 years of age), and 84 with late onset after this age (LOAD)], 50 individuals with Down's Syndrome (DS) and 5 patients with primary hippocampal sclerosis (HS). TDP-43-ir pathological changes were present, overall, in 34/1...

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Publication status:
Published

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Publisher copy:
10.1007/s00401-011-0879-y

Authors


Davidson, YS More by this author
Foulds, PG More by this author
Robinson, A More by this author
Thompson, JC More by this author
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Journal:
Acta neuropathologica
Volume:
122
Issue:
6
Pages:
703-713
Publication date:
2011-12-05
DOI:
EISSN:
1432-0533
ISSN:
0001-6322
URN:
uuid:981c5d6e-e6cb-474d-97da-41904866213b
Source identifiers:
244068
Local pid:
pubs:244068

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