TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype.

Journal article

TDP-43 immunoreactive (TDP-43-ir) pathological changes were investigated in the temporal cortex and hippocampus of 11 patients with autosomal dominant familial forms of Alzheimer's disease (FAD), 169 patients with sporadic AD [85 with early onset disease (EOAD) (i.e before 65 years of age), and 84 with late onset after this age (LOAD)], 50 individuals with Down's Syndrome (DS) and 5 patients with primary hippocampal sclerosis (HS). TDP-43-ir pathological changes were present, overall, in 34/1...

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Authors: Davidson, Y; Raby, S; Foulds, P; Robinson, A; Thompson, J

• Publication status: Published
• Journal: Acta neuropathologica
• Volume: 122
• Issue: 6
• Pages: 703-713
• Publication date: 2011-12-01
• DOI: 10.1007/s00401-011-0879-y
• EISSN: 1432-0533
• ISSN: 0001-6322
• Language: English
• Keywords: Hippocampus; Male; Aged; DNA-Binding Proteins; Aging; Down Syndrome; Alzheimer Disease; Aged, 80 and over; tau Proteins; Middle Aged; Autopsy; Cohort Studies; Female; Humans; Adult; Apolipoproteins E; Retrospective Studies; Cognition; Genotype; Sclerosis; Phenotype