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Expression analysis in multiple muscle groups and serum reveals complexity in the microRNA transcriptome of the mdx mouse with implications for therapy.

Abstract:

MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression and are implicated in wide-ranging cellular processes and pathological conditions including Duchenne muscular dystrophy (DMD). We have compared differential miRNA expression in proximal and distal limb muscles, diaphragm, heart and serum in the mdx mouse relative to wild-type controls. Global transcriptome analysis revealed muscle-specific patterns of differential miRNA expression as well as a number of changes common ...

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Publication status:
Published

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Publisher copy:
10.1038/mtna.2012.26

Authors


Roberts, TC More by this author
Blomberg, KE More by this author
McClorey, G More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford
Godfrey, C More by this author
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Journal:
Molecular therapy. Nucleic acids
Volume:
1
Issue:
8
Pages:
e39
Publication date:
2012
DOI:
EISSN:
2162-2531
ISSN:
2162-2531
URN:
uuid:981a9217-de46-4fc2-87bd-434c7ada74f1
Source identifiers:
364429
Local pid:
pubs:364429
Language:
English
Keywords:

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