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Journal article

Systemic anti-tumor necrosis factor alpha therapy in rheumatoid arthritis down-regulates synovial tumor necrosis factor alpha synthesis.

Abstract:

OBJECTIVE: To investigate the hypothesis that tumor necrosis factor alpha (TNFalpha) blockade in rheumatoid arthritis (RA) diminishes synovial synthesis of TNFalpha, interleukin-1alpha (IL-1alpha), and IL-1beta. METHODS: Patients with active RA received a single 10 mg/kg infusion of infliximab. Multiple synovial biopsy specimens were obtained from a knee the day before infusion and 14 days later. A modified immunohistochemical method detecting cytokine-producing rather than cytokine-binding c...

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Publication status:
Published

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Journal:
Arthritis and rheumatism
Volume:
43
Issue:
11
Pages:
2391-2396
Publication date:
2000-11-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:9818cf86-4278-4cb5-8c6f-2715960f1648
Source identifiers:
227041
Local pid:
pubs:227041

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