- Abstract:
-
OBJECTIVE: To investigate the hypothesis that tumor necrosis factor alpha (TNFalpha) blockade in rheumatoid arthritis (RA) diminishes synovial synthesis of TNFalpha, interleukin-1alpha (IL-1alpha), and IL-1beta. METHODS: Patients with active RA received a single 10 mg/kg infusion of infliximab. Multiple synovial biopsy specimens were obtained from a knee the day before infusion and 14 days later. A modified immunohistochemical method detecting cytokine-producing rather than cytokine-binding c...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/1529-0131(200011)43:11<2391::aid-anr3>3.0.co;2-f
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- Journal:
- Arthritis and rheumatism
- Volume:
- 43
- Issue:
- 11
- Pages:
- 2391-2396
- Publication date:
- 2000-11-05
- DOI:
- EISSN:
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1529-0131
- ISSN:
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0004-3591
- URN:
-
uuid:9818cf86-4278-4cb5-8c6f-2715960f1648
- Source identifiers:
-
227041
- Local pid:
- pubs:227041
- Copyright date:
- 2000
Journal article
Systemic anti-tumor necrosis factor alpha therapy in rheumatoid arthritis down-regulates synovial tumor necrosis factor alpha synthesis.
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