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Journal article

The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells.

Abstract:

The interaction between a T cell and an antigen-presenting cell (APC) can trigger a signaling response that leads to T cell activation. Prior studies have shown that ligation of the T cell receptor (TCR) triggers a signaling cascade that proceeds through the coalescence of TCR and various signaling molecules (e.g., the kinase Lck and adaptor protein LAT [linker for T cell activation]) into microdomains on the plasma membrane. In this study, we investigated another ligand-receptor interaction ...

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Publisher copy:
10.1083/jcb.200809136

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of cell biology
Volume:
185
Issue:
3
Pages:
521-534
Publication date:
2009-05-01
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Source identifiers:
426298
Language:
English
Keywords:
Pubs id:
pubs:426298
UUID:
uuid:9816cf8a-45dc-422e-ac2e-ea3b840c4284
Local pid:
pubs:426298
Deposit date:
2014-07-10

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