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Journal article

CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner.

Abstract:

CD161(++) CD8(+) T cells represent a novel subset that is dominated in adult peripheral blood by mucosal-associated invariant T (MAIT) cells, as defined by the expression of a variable-α chain 7.2 (Vα7.2)-Jα33 TCR, and IL-18Rα. Stimulation with IL-18+IL-12 is known to induce IFN-γ by both NK cells and, to a more limited extent, T cells. Here, we show the CD161(++) CD8(+) T-cell population is the primary T-cell population triggered by this mechanism. Both CD161(++) Vα7.2(+) and CD161(++) Vα7.2...

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Publication status:
Published

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Publisher copy:
10.1002/eji.201343509

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Journal:
European journal of immunology
Volume:
44
Issue:
1
Pages:
195-203
Publication date:
2014-01-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:9812d79e-a016-4fcf-a155-61f353d81ece
Source identifiers:
429253
Local pid:
pubs:429253

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