Expression and cellular localization of vascular endothelial growth factor A and its receptors in acute and chronic leukemias: an immunohistochemical study.

Journal article

We aimed to study the expression of phosphorylated vascular endothelial growth factor receptor 2 (pVEGFR-2), a membrane-bound tyrosine kinase receptor to vascular endothelial growth factor, in 76 cases of leukemia and nonneoplastic myeloproliferative disease and in 8 reactive bone marrows. The microvessel density (MVD) and the expression of both pVEGFR-2 and its ligand, VEGFA, were evaluated in these cases. We used archival cases and immunohistochemistry with a monoclonal antibody generated b...

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Authors: Zhang, Y; Pillai, G; Gatter, K; Blázquez, C; Turley, H

• Publication status: Published
• Journal: Human pathology
• Volume: 36
• Issue: 7
• Pages: 797-805
• Publication date: 2005-07-01
• DOI: 10.1016/j.humpath.2005.05.015
• EISSN: 1532-8392
• ISSN: 0046-8177
• Language: English
• Keywords: Humans; Middle Aged; Adult; Leukemia, Myeloid, Acute; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Precursor Cell Lymphoblastic Leukemia-Lymphoma; von Willebrand Factor; Bone Marrow; Microcirculation; Phosphorylation; Cell Nucleus; Vascular Endothelial Growth Factor Receptor-2