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Plasticity associated with Up/Down states in the mouse barrel cortex

Abstract:

Slow wave sleep is characterised by synchronised slow oscillations, which manifest themselves in cortical neurons as depolarised Up states and more hyperpolarised, silent Down states. Up/Down states have been implicated in synaptic plasticity during sleep-associated memory consolidation. However, the underlying mechanism is not well-understood.

I used the mouse somatosensory barrel cortex as a model system to investigate whether Up states and Down states differentially facilitate sy...

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Department:
Physiology Anatomy and Genetics
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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