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Advancing the management and control of typhoid fever: a review of the historical role of human challenge studies.

Abstract:

Typhoid infection causes considerable morbidity and mortality worldwide, particularly in settings where lack of clean water and inadequate sanitation facilitate disease spread through faecal-oral transmission. Improved understanding of the pathogenesis, immune control and microbiology of Salmonella Typhi infection can help accelerate the development of improved vaccines and diagnostic tests necessary for disease control. S. Typhi is a human-restricted pathogen; therefore animal models are lim...

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Publication status:
Published

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Publisher copy:
10.1016/j.jinf.2014.01.006

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Journal:
The Journal of infection
Volume:
68
Issue:
5
Pages:
405-418
Publication date:
2014-05-05
DOI:
EISSN:
1532-2742
ISSN:
0163-4453
URN:
uuid:9809fbc6-08ef-440c-92dc-c8a2c967cf00
Source identifiers:
447860
Local pid:
pubs:447860

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