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mTORC1 signalling mediates PI3K-dependent large lipid droplet accumulation in Drosophila ovarian nurse cells

Abstract:

Insulin and insulin-like growth factor signalling (IIS), which is primarily mediated by the PI3-kinase (PI3K)/PTEN/Akt kinase signalling cassette, is a highly evolutionary conserved pathway involved in co-ordinating growth, development, ageing and nutrient homeostasis with dietary intake. It controls transcriptional regulators, in addition to promoting signalling by mechanistic Target of Rapamycin (mTOR) Complex 1 (mTORC1), which stimulates biosynthesis of proteins and other macromolecules, a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1242/bio.022210

Authors


Mensah, LB More by this author
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Department:
St Hughs College
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Grant:
BDA: RD02/0002540
Association for International Cancer Research More from this funder
Publisher:
Company of Biologists Publisher's website
Journal:
Biology Open Journal website
Volume:
6
Issue:
5
Pages:
563-570
Publication date:
2017-03-16
Acceptance date:
2017-03-15
DOI:
ISSN:
2046-6390
Pubs id:
pubs:686677
URN:
uri:98056d43-fb7c-4e69-8b33-cdf1de039612
UUID:
uuid:98056d43-fb7c-4e69-8b33-cdf1de039612
Local pid:
pubs:686677
Language:
English
Keywords:

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